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Tramadol is a prescription pain medication used to treat moderate to moderately severe pain. It is considered a weaker opioid analgesic, but it also acts on neurotransmitters in the brain to provide pain relief. Tramadol has both opioid and non-opioid mechanisms of action, making it somewhat unique among painkillers.

Key Points about Tramadol:

  • Mechanism of Action: Tramadol works by binding to opioid receptors in the brain (like other opioids) and also inhibits the reuptake of serotonin and norepinephrine, which enhances its pain-relieving effects.
  • Forms: Available in immediate-release and extended-release formulations. The extended-release form is used for chronic pain that requires continuous, long-term treatment.
  • Uses: Prescribed for moderate to moderately severe pain, such as after surgery or for chronic conditions like arthritis. It's generally considered less potent than other opioids, making it a common choice for moderate pain.
  • Side Effects: Common side effects include nausea, dizziness, constipation, drowsiness, and headache. Serious side effects can include seizures, serotonin syndrome (especially when combined with other serotonergic drugs), and respiratory depression.
  • Risks: Like other opioids, tramadol carries a risk of abuse, dependence, and withdrawal symptoms if used long-term. However, it is considered less habit-forming than stronger opioids like oxycodone or morphine.
  • Warnings: Tramadol is metabolized by the liver into a more potent active form, and people with certain genetic variations (CYP2D6 ultra-rapid metabolizers) may process the drug too quickly, increasing the risk of side effects or overdose. It can also lower the seizure threshold, so it is used cautiously in people with a history of seizures.
Tramadol is classified as a Schedule IV controlled substance in the U.S., indicating a lower potential for abuse compared to other opioids, but it should still be used under the guidance of a healthcare provider to avoid complications or misuse.