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Tapentadol is a strong pain medication used to manage moderate to severe pain. The 100mg dose is typically prescribed for more intense or persistent pain conditions. Tapentadol works in two ways: it acts as an opioid agonist, binding to opioid receptors in the brain and spinal cord to alter pain perception, and it also inhibits the reuptake of norepinephrine, a neurotransmitter that helps reduce pain signals.