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Codeine involves its conversion in the body to morphine, a more potent opioid. This conversion occurs primarily in the liver, where a portion of the administered dose is metabolized by the enzyme CYP2D6. Due to this metabolic pathway, individual responses to Codeine can vary significantly; some patients may find it highly effective, while others may experience minimal analgesic effects or increased side effects. This variability underscores the importance of personalized medicine in prescribing opioids.
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